HOMER3-AS1

Across TCGA pan-cancer cohorts, HOMER3-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated HOMER3-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher HOMER3-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HOMER3-AS1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and KIRP show a favorable association.

KIRC, BLCA, and KIRP are the cancer types where HOMER3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	IV	0.354	0.632	<.001	68	view →
BLCA	OS	Median	II,III,IV	0.696	0.529	.001	66	view →
KIRP	DFS	Tertile	IV	0.621	0.030	.002	63	view →
LIHC	OS	Tertile	All	0.709	0.854	.001	48	view →
HNSC	DFS	Quartile	IV	0.524	0.762	<.001	43	view →
ACC	DFS	Tertile	All	0.258	0.700	<.001	36	view →
LAML	DFS	Quartile	All	0.590	0.159	.005	30	view →
ESCA	DFS	Median	All	0.927	0.454	.004	24	view →
COAD	DFS	Quartile	All	0.386	0.672	.003	21	view →
THCA	OS	Median	II,III,IV	0.559	1.000	.005	19	view →
OV	OS	Median	II,III,IV	0.290	0.346	.027	18	view →
CHOL	OS	Quartile	II,III,IV	1.000	0.101	.010	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

HOMER3-AS1–KIRC (DFS)

Open the KIRC breakdown →