HOMER3-AS1

Across TCGA pan-cancer cohorts, HOMER3-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of HOMER3-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HOMER3-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HOMER3-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, HNSC, and THCA are the cancer types where HOMER3-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOMER3-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.324	<.001	12	view →
HNSC	Female	All	+0.590	<.001	10	view →
THCA	Male	II,III,IV	−0.651	<.001	5	view →
LUSC	Female	All	+0.430	.001	5	view →
KICH	All	All	−0.418	<.001	5	view →
LIHC	All	II,III,IV	+0.202	.003	4	view →
KIRP	Male	All	+0.419	<.001	2	view →
COAD	Female	IV	−0.360	.018	1	view →
STAD	Male	II,III,IV	+0.258	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

HOMER3-AS1–KIRC

Open the KIRC breakdown →