HOMER2

Across TCGA cell cohorts, HOMER2 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HOMER2-associated genes across cancer lineages are C8orf34, ZCCHC13, and FAM47C. Each is linked with HOMER2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOMER2-to-partner and partner-to-HOMER2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C8orf34 grouped by HOMER2-low versus HOMER2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOMER2→partner) and Y-score (partner→HOMER2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C8orf34 →	+0.114	+3.769	<.001	.008	3	1
BLOOD_Leukemia	ZCCHC13 →	+0.018	+4.984	<.001	.002	3	1
BLOOD_Leukemia	FAM47C →	+0.017	+4.269	<.001	.002	3	1
BLOOD_Leukemia	KRTAP5-1 →	+0.094	+3.855	.003	.007	3	1
BLOOD_Leukemia	GRXCR1 →	+0.014	+4.984	<.001	.002	3	1
BLOOD_Leukemia	PRAMEF4 →	+0.010	+4.984	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

C8orf34 by HOMER2 expression — BLOOD_Leukemia

Explore this box plot interactively →