Across TCGA patient cohorts, HOATZ mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOATZ-associated genes across cancer lineages are JNK_pT183_Y185, MEK1, and Myosin-IIa_pS1943. Each is linked with HOATZ in more than 1 cancer types. Because this analysis shows association rather than direction, both HOATZ-to-partner and partner-to-HOATZ results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOATZ→partner) and Y-score (partner→HOATZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.162	-2.321	.016	.034	3	1
UCEC	MEK1 →	+0.349	+2.321	.017	.034	3	1
UCEC	Myosin-IIa_pS1943 →	+0.190	+2.584	.022	.010	3	1
UCEC	Myosin-IIa →	+0.166	+1.707	.035	.027	3	1
UCEC	Notch1 →	+0.191	+3.335	<.001	.005	3	1
UCEC	N-Ras →	-0.105	-1.893	.028	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

HOATZ survival (RNA) · tumor vs normal (RNA) · all HOATZ data types