HNRNPD

Across TCGA pan-cancer cohorts, HNRNPD mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HNRNPD data layer compared with 28 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HNRNPD mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HNRNPD expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and GBM are the cancer types where HNRNPD mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.791	0.392	.002	29	view →
LUAD	OS	Median	II,III,IV	1.000	0.339	<.001	24	view →
GBM	OS	Quartile	All	0.552	0.270	.005	9	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
LSCC	DFS	Tertile	III,IV	0.407	0.896	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HNRNPD–CCRCC (DFS)

Open the CCRCC breakdown →