HNRNPCL3

Across TCGA patient cohorts, HNRNPCL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,757 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible HNRNPCL3-associated GO terms across cancer lineages are Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery, RNA polymerase II preinitiation complex assembly, and Ribosome assembly. Each is linked with HNRNPCL3 in more than 11 cancer types. Because this analysis shows association rather than direction, both HNRNPCL3-to-partner and partner-to-HNRNPCL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery grouped by HNRNPCL3-low versus HNRNPCL3-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HNRNPCL3→partner) and Y-score (partner→HNRNPCL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.151	+0.335	<.001	.001	3	12
STAD	RNA polymerase II preinitiation complex assembly →	+0.024	+0.054	.002	.001	3	11
STAD	Ribosome assembly →	+0.048	+0.074	<.001	.002	3	11
STAD	Transcription initiation at RNA polymerase II promoter →	+0.025	+0.058	.002	<.001	3	11
STAD	Positive regulation of telomere maintenance via telomere lengthening →	+0.040	+0.039	<.001	<.001	2	11
STAD	Ribosomal small subunit biogenesis →	+0.049	+0.069	<.001	.004	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,757 associations by consensus.

Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery by HNRNPCL3 expression — SCLC

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