Across TCGA pan-cancer cohorts, HNRNPCL3 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of HNRNPCL3’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HNRNPCL3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HNRNPCL3 is over-expressed in tumor.
HNSC and LIHC are the cancer types where HNRNPCL3 tumor–normal differential expression is most reproducible.