HNRNPA2B1

Across TCGA pan-cancer cohorts, HNRNPA2B1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated HNRNPA2B1 data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher HNRNPA2B1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HNRNPA2B1 expression acts as an unfavorable survival marker, although some lineages such as SCLC and THYM show a favorable association.

ACC, SCLC, and LUAD are the cancer types where HNRNPA2B1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.329	0.825	<.001	117	view →
SCLC	OS	Tertile	All	0.649	0.226	<.001	73	view →
LUAD	OS	Tertile	All	0.250	0.446	<.001	54	view →
LGG	DFS	Median	All	0.630	0.840	<.001	54	view →
LIHC	DFS	Median	All	0.468	0.612	<.001	53	view →
KIRC	DFS	Quartile	II,III,IV	0.344	0.616	.003	42	view →
SARC	OS	Quartile	All	0.597	0.855	<.001	35	view →
MESO	OS	Median	All	0.461	0.617	.013	33	view →
KICH	OS	Median	II,III,IV	0.648	0.958	.006	32	view →
KIRP	DFS	Median	III,IV	0.151	0.566	.006	25	view →
CESC	DFS	Median	IV	0.323	0.678	.010	18	view →
THYM	OS	Median	II,III,IV	0.960	0.629	<.001	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

HNRNPA2B1–ACC (DFS)

Open the ACC breakdown →