HNRNPA2B1

Across TCGA pan-cancer cohorts, HNRNPA2B1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of HNRNPA2B1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HNRNPA2B1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HNRNPA2B1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, STAD, and LIHC are the cancer types where HNRNPA2B1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HNRNPA2B1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.853	<.001	12	view →
STAD	Male	II,III,IV	+1.066	<.001	9	view →
LIHC	All	II,III,IV	+0.863	<.001	9	view →
BLCA	All	III,IV	+0.722	<.001	9	view →
COAD	Male	II,III,IV	+0.671	<.001	9	view →
THCA	All	II,III,IV	−0.390	<.001	9	view →
LUSC	Male	II,III,IV	+0.710	<.001	8	view →
LUAD	Male	II,III,IV	+0.676	<.001	8	view →
KICH	Female	All	−0.980	<.001	7	view →
UCEC	All	III,IV	+0.658	.020	6	view →
BRCA	All	III,IV	+0.622	<.001	6	view →
CHOL	Male	All	+1.736	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

HNRNPA2B1–HNSC

Open the HNSC breakdown →