HNRNPA1

Across TCGA patient cohorts, HNRNPA1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HNRNPA1-associated genes across cancer lineages are ASNS, MEK1, and Akt_pS473. Each is linked with HNRNPA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HNRNPA1-to-partner and partner-to-HNRNPA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by HNRNPA1-low versus HNRNPA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNRNPA1→partner) and Y-score (partner→HNRNPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.597	+2.321	<.001	.034	3	3
UCEC	MEK1 →	+0.432	+2.321	.018	.035	3	2
UCEC	Akt_pS473 →	+0.718	+2.321	.045	.035	3	2
UCEC	Akt_pT308 →	+0.671	+2.321	.033	.035	3	2
UCEC	PRAS40_pT246 →	+0.217	+2.335	.011	.020	3	1
UCEC	S6_pS240_S244 →	+0.471	+2.321	.021	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ASNS by HNRNPA1 expression — UCEC

Explore this box plot interactively →