HNRNPA1

Across TCGA pan-cancer cohorts, HNRNPA1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of HNRNPA1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HNRNPA1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HNRNPA1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, COAD, and LIHC are the cancer types where HNRNPA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HNRNPA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.599	<.001	11	view →
COAD	Female	II,III,IV	+0.908	<.001	10	view →
LIHC	Female	II,III,IV	+1.527	<.001	9	view →
STAD	Male	II,III,IV	+0.814	<.001	8	view →
LUSC	Male	II,III,IV	+0.706	<.001	8	view →
HNSC	Male	All	+0.603	<.001	8	view →
CHOL	Male	All	+2.880	<.001	5	view →
READ	All	All	+0.665	.001	5	view →
LUAD	All	All	+0.277	<.001	5	view →
KICH	Female	All	−0.949	.003	2	view →
KIRP	All	II,III,IV	+0.488	.025	2	view →
ESCA	All	All	+0.777	.007	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

HNRNPA1–KIRC

Open the KIRC breakdown →