HNMT

Across TCGA pan-cancer cohorts, HNMT Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HNMT data layer compared with 25 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HNMT Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HNMT expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, LUAD, and DLBC are the cancer types where HNMT Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.156	0.710	.002	24	view →
LUAD	OS	Median	All	0.245	0.835	<.001	21	view →
DLBC	DFS	Median	II,III,IV	0.022	0.837	<.001	12	view →
UCEC	OS	Median	All	1.000	0.650	.012	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HNMT–HNSC (OS)

Open the HNSC breakdown →