HNMT

Across TCGA pan-cancer cohorts, HNMT RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of HNMT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where HNMT RNA is repressed in tumor relative to normal tissue. In most cancer types HNMT is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and UCEC are the cancer types where HNMT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HNMT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−2.755	<.001	11	view →
KIRP	All	III,IV	−1.326	<.001	9	view →
UCEC	All	III,IV	−2.570	<.001	8	view →
LUSC	Male	II,III,IV	−1.706	<.001	8	view →
HNSC	Male	All	−0.896	<.001	8	view →
BRCA	All	II,III,IV	−0.668	<.001	6	view →
THCA	Female	All	−0.665	<.001	6	view →
KIRC	Male	All	+0.467	<.001	6	view →
LUAD	All	III,IV	−0.713	.003	4	view →
STAD	Male	II,III,IV	+0.720	.017	2	view →
PRAD	All	All	−0.369	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

HNMT–KICH

Open the KICH breakdown →