HNMT

Across TCGA pan-cancer cohorts, HNMT mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HNMT data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HNMT mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HNMT expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

COAD, CCRCC, and UCEC are the cancer types where HNMT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.912	.013	42	view →
CCRCC	DFS	Median	All	0.980	0.854	.001	39	view →
UCEC	OS	Tertile	III,IV	0.345	1.000	.013	12	view →
LUAD	DFS	Quartile	III,IV	0.298	0.940	<.001	3	view →
LSCC	DFS	Quartile	II,III,IV	0.843	1.000	.044	1	view →
PDAC	DFS	Quartile	III,IV	1.000	0.555	.046	1	view →
HNSC	DFS	Median	II,III,IV	0.909	0.983	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

HNMT–COAD (DFS)

Open the COAD breakdown →