HNMT

Across TCGA patient cohorts, HNMT protein abundance is significantly associated with the RNA expression of many other genes, with 20,583 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HNMT-associated genes across cancer lineages are LRRN4CL, DEPDC1, and CDKN3. Each is linked with HNMT in more than 8 cancer types. Because this analysis shows association rather than direction, both HNMT-to-partner and partner-to-HNMT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HNMT versus LRRN4CL in BRCA, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNMT→partner) and Y-score (partner→HNMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LRRN4CL →	+1.076	+0.438	<.001	<.001	3	9
UCEC	DEPDC1 →	-1.354	-0.527	<.001	<.001	3	9
LUAD	CDKN3 →	-1.002	-0.559	<.001	<.001	3	8
BRCA	UBE2S →	-1.117	-0.426	<.001	<.001	3	8
BRCA	PLCL1 →	+0.791	+0.430	<.001	<.001	3	8
BRCA	CDC20 →	-1.377	-0.555	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,583 associations by consensus.

HNMT vs LRRN4CL — BRCA

Explore this scatter interactively →