HNMT

Across TCGA patient cohorts, HNMT mutation is significantly associated with the RNA expression of many other genes, with 1,573 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HNMT-associated genes across cancer lineages are LINC01159, RAB9BP1, and RBPMS2P1. Each is linked with HNMT in more than 1 cancer types. Because this analysis shows association rather than direction, both HNMT-to-partner and partner-to-HNMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01159 grouped by HNMT-low versus HNMT-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNMT→partner) and Y-score (partner→HNMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	LINC01159 →	+0.462	+4.363	<.001	.007	3	2
BLCA	RAB9BP1 →	+0.104	+4.899	<.001	.005	3	2
BLCA	RBPMS2P1 →	+0.569	+4.788	<.001	.006	3	2
UCEC	SKA1 →	+0.751	+2.609	<.001	<.001	3	2
UCEC	VPS37A →	+0.485	+1.936	.002	.003	3	2
UCEC	H2AZ1 →	+0.548	+1.958	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,573 associations by consensus.

LINC01159 by HNMT expression — BLCA

Explore this box plot interactively →