HNMT

Across TCGA patient cohorts, HNMT mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HNMT-associated genes across cancer lineages are A-Raf_pS299, ERK2, and PKC-delta_pS664. Each is linked with HNMT in more than 1 cancer types. Because this analysis shows association rather than direction, both HNMT-to-partner and partner-to-HNMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by HNMT-low versus HNMT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNMT→partner) and Y-score (partner→HNMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.149	-3.169	.001	.018	3	2
UCEC	ERK2 →	+0.181	+3.321	.016	.009	3	2
UCEC	PKC-delta_pS664 →	-0.118	-2.584	.012	.010	3	2
UCEC	Rab25 →	-0.386	-1.874	.002	.049	3	2
UCEC	TFRC →	+0.494	+1.584	.017	.036	3	2
UCEC	C-Raf →	+0.248	+3.169	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

A-Raf_pS299 by HNMT expression — UCEC

Explore this box plot interactively →