HNMT

Across TCGA cell cohorts, HNMT RNA expression is significantly associated with the go_rna of many other GO terms, with 4,574 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HNMT-associated GO terms across cancer lineages are Imidazole-containing compound catabolic process, L-histidine catabolic process, and Imidazole-containing compound metabolic process. Each is linked with HNMT in more than 15 cancer types. Because this analysis shows association rather than direction, both HNMT-to-partner and partner-to-HNMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Imidazole-containing compound catabolic process grouped by HNMT-low versus HNMT-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HNMT→partner) and Y-score (partner→HNMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Imidazole-containing compound catabolic process →	+1.440	+2.682	<.001	<.001	3	16
KIDNEY	L-histidine catabolic process →	+1.440	+2.682	<.001	<.001	3	16
LUNG_NSCLC_LUAD	Imidazole-containing compound metabolic process →	+1.342	+2.513	<.001	<.001	3	15
SKIN	Histamine metabolic process →	+1.572	+2.663	<.001	<.001	3	13
LUNG_SCLC	Negative regulation of endopeptidase activity →	+1.086	+1.658	.002	.008	3	9
SOFT_TISSUE	Negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell →	+0.773	+2.043	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,574 associations by consensus.

Imidazole-containing compound catabolic process by HNMT expression — KIDNEY

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