HNF4G

Across TCGA patient cohorts, HNF4G mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HNF4G-associated genes across cancer lineages are Caspase-8, 14-3-3_beta, and EGFR_pY1068. Each is linked with HNF4G in more than 1 cancer types. Because this analysis shows association rather than direction, both HNF4G-to-partner and partner-to-HNF4G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by HNF4G-low versus HNF4G-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNF4G→partner) and Y-score (partner→HNF4G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.219	-2.880	.013	.001	3	2
UCEC	14-3-3_beta →	-0.073	-1.973	.038	.029	3	1
UCEC	EGFR_pY1068 →	-0.269	-2.392	.002	<.001	3	1
UCEC	EGFR →	-0.151	-1.662	.007	.011	3	1
UCEC	ERK2 →	+0.240	+2.392	<.001	<.001	3	1
UCEC	HER2_pY1248 →	-0.188	-2.000	.046	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Caspase-8 by HNF4G expression — UCEC

Explore this box plot interactively →