HNF4G

Across TCGA pan-cancer cohorts, HNF4G RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of HNF4G’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HNF4G RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HNF4G is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KIRC, LUAD, and KICH are the cancer types where HNF4G tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HNF4G RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.448	<.001	10	view →
LUAD	Male	II,III,IV	+2.308	<.001	9	view →
KICH	Female	All	−2.190	<.001	8	view →
STAD	All	II,III,IV	+2.134	<.001	8	view →
LUSC	All	All	+0.830	<.001	5	view →
COAD	All	All	−0.763	<.001	4	view →
CHOL	All	All	+1.437	<.001	3	view →
UCEC	All	All	+0.619	.020	2	view →
PRAD	All	All	+0.281	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

HNF4G–KIRC

Open the KIRC breakdown →