HNF4G

Across TCGA cell cohorts, HNF4G mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HNF4G-associated genes across cancer lineages are KRT222, GOLGA6L6, and VN1R3. Each is linked with HNF4G in more than 1 cancer types. Because this analysis shows association rather than direction, both HNF4G-to-partner and partner-to-HNF4G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT222 grouped by HNF4G-low versus HNF4G-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNF4G→partner) and Y-score (partner→HNF4G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KRT222 →	+0.475	+3.781	.004	.003	3	2
BLOOD_Lymphoma	GOLGA6L6 →	+1.333	+4.927	<.001	.001	3	2
LUNG_NSCLC_LUAD	VN1R3 →	+0.010	+3.944	<.001	.006	3	2
LUNG_NSCLC_LUSC	UTF1 →	+0.136	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
OESOPHAGUS	HMGB4 →	+0.043	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

KRT222 by HNF4G expression — SKIN

Explore this box plot interactively →