HNF4A

Across TCGA patient cohorts, HNF4A protein abundance is significantly associated with the RNA expression of many other genes, with 13,140 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HNF4A-associated genes across cancer lineages are CSF3R, ID1, and FFAR2. Each is linked with HNF4A in more than 2 cancer types. Because this analysis shows association rather than direction, both HNF4A-to-partner and partner-to-HNF4A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HNF4A versus CSF3R in GBM, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNF4A→partner) and Y-score (partner→HNF4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CSF3R →	+1.364	+1.217	<.001	<.001	3	3
OV	ID1 →	+1.767	+1.214	<.001	.002	3	3
LUAD	FFAR2 →	+1.155	+1.157	<.001	<.001	3	3
GBM	ADGRE3 →	+0.565	+0.926	<.001	<.001	3	3
GBM	CXCR2 →	+0.885	+1.169	<.001	<.001	3	3
OV	RAB40C →	+0.723	+1.188	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,140 associations by consensus.

HNF4A vs CSF3R — GBM

Explore this scatter interactively →