Across TCGA pan-cancer cohorts, HNF4A-AS1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated HNF4A-AS1 data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher HNF4A-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HNF4A-AS1 expression acts as an unfavorable survival marker, although some lineages such as LIHC and PAAD show a favorable association.

CESC, KICH, and LIHC are the cancer types where HNF4A-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Tertile	II,III,IV	0.617	0.852	.004	78	view →
KICH	DFS	Tertile	II,III,IV	0.460	1.000	<.001	64	view →
LIHC	DFS	Median	All	0.547	0.331	<.001	46	view →
CHOL	DFS	Quartile	II,III,IV	0.075	0.607	.003	40	view →
PAAD	OS	Quartile	II,III,IV	0.722	0.230	<.001	37	view →
KIRP	OS	Median	II,III,IV	0.844	0.624	.007	37	view →
GBM	OS	Tertile	All	0.069	0.415	<.001	27	view →
LUAD	DFS	Tertile	III,IV	0.323	0.668	.003	27	view →
MESO	OS	Tertile	IV	0.077	0.592	.019	18	view →
ESCA	OS	Median	All	0.617	1.000	.009	15	view →
ACC	OS	Tertile	II,III,IV	0.333	0.656	.025	12	view →
SKCM	DFS	Tertile	All	0.556	0.747	.001	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

Exploration

Same gene, other analysis: HNF4A-AS1 tumor-vs-normal RNA expression · all HNF4A-AS1 data types