Across TCGA pan-cancer cohorts, HNF4A-AS1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of HNF4A-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where HNF4A-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types HNF4A-AS1 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and KICH are the cancer types where HNF4A-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HNF4A-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	−3.032	<.001	11	view →
KIRC	Male	All	−1.883	<.001	11	view →
KICH	All	II,III,IV	−2.140	<.001	8	view →
LIHC	Female	All	−1.952	<.001	7	view →
CHOL	Female	All	−4.706	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: HNF4A-AS1 RNA expression & survival · all HNF4A-AS1 data types