HNF1B

Across TCGA pan-cancer cohorts, HNF1B mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HNF1B data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HNF1B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HNF1B expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where HNF1B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.928	0.105	.006	30	view →
LSCC	OS	Median	III,IV	1.000	0.515	.026	13	view →
LUAD	OS	Quartile	III,IV	0.821	0.349	.007	6	view →
PDAC	OS	Median	All	0.896	0.805	.014	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HNF1B–CCRCC (DFS)

Open the CCRCC breakdown →