HNF1B

Across TCGA pan-cancer cohorts, HNF1B RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of HNF1B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where HNF1B RNA is repressed in tumor relative to normal tissue. In most cancer types HNF1B is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, LUSC, and KIRP are the cancer types where HNF1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HNF1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−3.109	<.001	11	view →
LUSC	Female	II,III,IV	−3.344	<.001	8	view →
KIRP	All	II,III,IV	+0.901	<.001	8	view →
THCA	All	All	+0.174	<.001	8	view →
STAD	Male	All	+2.032	<.001	5	view →
COAD	Female	All	−0.573	.003	4	view →
CHOL	Female	All	+4.003	<.001	3	view →
HNSC	Male	IV	+0.061	.021	3	view →
KIRC	Male	II,III,IV	−0.522	.009	2	view →
LUAD	All	All	−0.426	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

HNF1B–KICH

Open the KICH breakdown →