HNF1B

Across TCGA patient cohorts, HNF1B RNA expression is significantly associated with the protein abundance of many other proteins, with 16,327 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HNF1B-associated proteins across cancer lineages are HNF1B_S49, RBM47, and ANXA4. Each is linked with HNF1B in more than 4 cancer types. Because this analysis shows association rather than direction, both HNF1B-to-partner and partner-to-HNF1B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HNF1B versus HNF1B_S49 in LUAD, with a Pearson correlation of 0.68.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HNF1B→partner) and Y-score (partner→HNF1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HNF1B_S49 →	+1.162	+1.077	<.001	<.001	3	5
CCRCC	RBM47 →	+0.274	+0.986	.001	<.001	3	4
UCEC	ANXA4 →	+0.402	+1.010	<.001	<.001	3	4
GBM	CAMSAP3 →	+0.389	+0.048	<.001	.001	3	4
OV	COBL →	+1.522	+2.272	.004	.001	3	4
CCRCC	FBLN5 →	+0.557	+0.548	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,327 associations by consensus.

HNF1B vs HNF1B_S49 — LUAD

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