HNF1B

Across TCGA patient cohorts, HNF1B protein abundance is significantly associated with the RNA expression of many other genes, with 6,944 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible HNF1B-associated genes across cancer lineages are GAL3ST1, DPP4, and HNF1A-AS1. Each is linked with HNF1B in more than 2 cancer types. Because this analysis shows association rather than direction, both HNF1B-to-partner and partner-to-HNF1B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HNF1B versus GAL3ST1 in LUAD, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNF1B→partner) and Y-score (partner→HNF1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GAL3ST1 →	+1.042	+0.583	<.001	<.001	3	3
UCEC	DPP4 →	+1.621	+0.716	.001	.001	3	3
UCEC	HNF1A-AS1 →	+1.975	+0.893	.002	.001	3	3
CCRCC	HOGA1 →	+0.982	+0.257	.001	.003	3	3
CCRCC	LGALS2 →	+1.221	+0.253	<.001	<.001	3	2
LUAD	DNAL4 →	+0.526	+0.436	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,944 associations by consensus.

HNF1B vs GAL3ST1 — LUAD

Explore this scatter interactively →