HNF1B

Across TCGA patient cohorts, HNF1B mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HNF1B-associated genes across cancer lineages are Chk2_pT68, eEF2K, and SF2. Each is linked with HNF1B in more than 1 cancer types. Because this analysis shows association rather than direction, both HNF1B-to-partner and partner-to-HNF1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk2_pT68 grouped by HNF1B-low versus HNF1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNF1B→partner) and Y-score (partner→HNF1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Chk2_pT68 →	-0.182	-3.312	.030	.010	3	2
UCEC	eEF2K →	+0.414	+3.000	.008	.036	3	2
SKCM	SF2 →	+0.144	+2.000	.011	.029	3	1
UCEC	EGFR_pY1068 →	-0.311	-2.700	.006	.006	3	1
UCEC	EGFR →	-0.172	-3.000	.016	.036	3	1
UCEC	eIF4G →	+0.307	+3.169	.028	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Chk2_pT68 by HNF1B expression — UCEC

Explore this box plot interactively →