HNF1B

Across TCGA cell cohorts, HNF1B RNA expression is significantly associated with the go_rna of many other GO terms, with 1,996 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HNF1B-associated GO terms across cancer lineages are Regulation of kidney size, Actomyosin contractile ring organization, and Positive regulation of amino acid metabolic process. Each is linked with HNF1B in more than 11 cancer types. Because this analysis shows association rather than direction, both HNF1B-to-partner and partner-to-HNF1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of kidney size grouped by HNF1B-low versus HNF1B-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HNF1B→partner) and Y-score (partner→HNF1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Regulation of kidney size →	+1.940	+3.071	<.001	<.001	3	12
OVARY	Actomyosin contractile ring organization →	+0.106	+2.174	.002	.002	3	7
KIDNEY	Positive regulation of amino acid metabolic process →	-0.202	-1.721	.001	.004	3	6
OVARY	Regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains →	+0.033	+1.677	.001	.005	3	6
LUNG_NSCLC_LUAD	Extrinsic apoptotic signaling pathway →	+0.049	+1.845	<.001	<.001	3	6
CNS	Protein poly-ADP-ribosylation →	+0.085	+0.046	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,996 associations by consensus.

Regulation of kidney size by HNF1B expression — BLOOD_Myeloma

Explore this box plot interactively →