HNF1B

Across TCGA cell cohorts, HNF1B mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible HNF1B-associated genes across cancer lineages are PRAMEF7, ZNRF4, and PRM2. Each is linked with HNF1B in more than 1 cancer types. Because this analysis shows association rather than direction, both HNF1B-to-partner and partner-to-HNF1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF7 grouped by HNF1B-low versus HNF1B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNF1B→partner) and Y-score (partner→HNF1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRAMEF7 →	+0.009	+4.539	.008	.007	3	1
UPPER_AERODIGESTIVE_TRACT	ZNRF4 →	+0.036	+4.209	.002	.006	3	1
UPPER_AERODIGESTIVE_TRACT	PRM2 →	+0.053	+4.209	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	TBXT →	+0.180	+4.209	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	C2orf80 →	+0.066	+4.209	<.001	.006	3	1
SKIN	LALBA →	+0.058	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PRAMEF7 by HNF1B expression — BLOOD_Leukemia

Explore this box plot interactively →