HNF1A

Across TCGA patient cohorts, HNF1A mutation is significantly associated with the RNA expression of many other genes, with 1,490 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HNF1A-associated genes across cancer lineages are RNU2-24P, MIR6893, and CERS3-AS1. Each is linked with HNF1A in more than 2 cancer types. Because this analysis shows association rather than direction, both HNF1A-to-partner and partner-to-HNF1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU2-24P grouped by HNF1A-low versus HNF1A-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNF1A→partner) and Y-score (partner→HNF1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RNU2-24P →	+0.210	+3.866	.005	.002	3	3
COAD	MIR6893 →	+0.582	+3.096	<.001	.005	3	3
LIHC	CERS3-AS1 →	+0.478	+3.630	.007	.008	3	2
SARC	KRTAP19-7 →	+0.085	+5.977	<.001	.001	3	2
SARC	LINC01438 →	+0.162	+5.152	<.001	.003	3	2
SARC	MIR6821 →	+0.550	+4.291	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,490 associations by consensus.

RNU2-24P by HNF1A expression — LIHC

Explore this box plot interactively →