HNF1A

Across TCGA pan-cancer cohorts, HNF1A RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated HNF1A data layer compared with 6 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher HNF1A RNA is associated with better overall survival. In most high-consensus cancer types, elevated HNF1A expression acts as an unfavorable survival marker, although some lineages such as KIRC and SCLC show a favorable association.

KIRC, MESO, and ACC are the cancer types where HNF1A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.716	0.544	<.001	176	view →
MESO	OS	Tertile	All	0.178	0.405	<.001	117	view →
ACC	OS	Median	All	0.754	0.946	<.001	109	view →
SCLC	OS	Tertile	All	0.581	0.163	<.001	60	view →
LGG	DFS	Median	All	0.654	0.796	<.001	43	view →
HNSC	OS	Tertile	IV	0.499	0.247	.001	39	view →
UCS	DFS	Quartile	III,IV	0.410	0.083	.018	34	view →
UVM	OS	Tertile	All	0.588	0.919	.024	22	view →
UCEC	DFS	Tertile	All	0.898	0.810	.007	22	view →
BRCA	DFS	Tertile	III,IV	0.848	0.699	.005	20	view →
TGCT	DFS	Tertile	All	0.538	0.823	.004	18	view →
CHOL	OS	Median	III,IV	0.286	1.000	.008	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

HNF1A–KIRC (OS)

Open the KIRC breakdown →