HNF1A

Across TCGA patient cohorts, HNF1A mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HNF1A-associated genes across cancer lineages are Fibronectin, ATM, and YAP_pS127. Each is linked with HNF1A in more than 2 cancer types. Because this analysis shows association rather than direction, both HNF1A-to-partner and partner-to-HNF1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by HNF1A-low versus HNF1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNF1A→partner) and Y-score (partner→HNF1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.256	-2.105	.034	.017	3	3
UCEC	ATM →	-0.645	-2.247	<.001	.001	3	3
BLCA	YAP_pS127 →	-0.551	-3.000	.007	.036	3	2
UCEC	Ku80 →	+0.204	+1.495	.019	.034	3	2
UCEC	MSH6 →	-0.509	-2.807	<.001	.002	3	2
UCEC	PDCD4 →	-0.408	-3.169	.018	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Fibronectin by HNF1A expression — UCEC

Explore this box plot interactively →