HNF1A

Across TCGA cell cohorts, HNF1A RNA expression is significantly associated with the go_rna of many other GO terms, with 2,609 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HNF1A-associated GO terms across cancer lineages are Renal D-glucose absorption, Aldehyde metabolic process, and Cellular response to rapamycin. Each is linked with HNF1A in more than 8 cancer types. Because this analysis shows association rather than direction, both HNF1A-to-partner and partner-to-HNF1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Renal D-glucose absorption grouped by HNF1A-low versus HNF1A-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HNF1A→partner) and Y-score (partner→HNF1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Renal D-glucose absorption →	+2.046	+3.910	<.001	<.001	3	9
STOMACH	Aldehyde metabolic process →	+0.084	+1.895	.003	<.001	3	8
STOMACH	Cellular response to rapamycin →	-0.197	-2.566	<.001	<.001	3	8
LIVER	Adenylate cyclase-activating serotonin receptor signaling pathway →	+0.193	+3.047	<.001	.001	3	7
BONE	Lactation →	+0.223	+0.123	<.001	<.001	3	7
KIDNEY	Positive regulation of mitochondrial membrane potential →	-0.166	-1.970	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,609 associations by consensus.

Renal D-glucose absorption by HNF1A expression — LIVER

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