HNF1A

Across TCGA cell cohorts, HNF1A mutation is significantly associated with the RNA expression of many other genes, with 211 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HNF1A-associated genes across cancer lineages are KRTAP10-1, AVP, and F9. Each is linked with HNF1A in more than 1 cancer types. Because this analysis shows association rather than direction, both HNF1A-to-partner and partner-to-HNF1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-1 grouped by HNF1A-low versus HNF1A-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNF1A→partner) and Y-score (partner→HNF1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KRTAP10-1 →	+0.034	+5.369	.002	.004	3	2
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	2
LUNG_SCLC	F9 →	+0.027	+4.643	<.001	.004	3	2
BLOOD_Leukemia	NKX2-6 →	+0.489	+5.786	<.001	<.001	3	2
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
SOFT_TISSUE	H2BC1 →	+0.433	+5.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 211 associations by consensus.

KRTAP10-1 by HNF1A expression — SOFT_TISSUE

Explore this box plot interactively →