HNF1A-AS1

Across TCGA patient cohorts, HNF1A-AS1 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,209 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HNF1A-AS1-associated proteins across cancer lineages are PLEKHA6, PPP1R18_S224, and MT2A_S58. Each is linked with HNF1A-AS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both HNF1A-AS1-to-partner and partner-to-HNF1A-AS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HNF1A-AS1 versus PLEKHA6 in PDAC, with a Pearson correlation of 0.70.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HNF1A-AS1→partner) and Y-score (partner→HNF1A-AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PLEKHA6 →	+0.562	+1.175	<.001	<.001	3	4
LUAD	PPP1R18_S224 →	-0.517	-0.886	<.001	.005	3	4
CCRCC	MT2A_S58 →	-1.363	-1.169	.002	.002	3	4
COAD	PKP4 →	+0.237	+0.654	.002	<.001	3	3
PDAC	PLEKHA6_S459 →	+0.921	+0.904	<.001	<.001	3	3
PDAC	PLEKHA6_S777 →	+1.125	+1.242	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,209 associations by consensus.

HNF1A-AS1 vs PLEKHA6 — PDAC

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