HNF1A-AS1

Across TCGA pan-cancer cohorts, HNF1A-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated HNF1A-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher HNF1A-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HNF1A-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BLCA show a favorable association.

ACC, UVM, and KIRC are the cancer types where HNF1A-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.433	0.886	.001	38	view →
UVM	OS	Quartile	All	0.662	0.894	.008	35	view →
KIRC	OS	Median	All	0.910	0.835	.002	26	view →
THCA	OS	Median	All	0.980	0.996	.013	25	view →
BLCA	OS	Tertile	All	0.678	0.551	.017	24	view →
LIHC	DFS	Median	All	0.475	0.607	.001	23	view →
READ	OS	Tertile	III,IV	0.819	0.462	.006	20	view →
KIRP	DFS	Median	IV	0.622	0.040	.006	20	view →
LUSC	OS	Median	II,III,IV	0.547	0.700	.004	19	view →
MESO	OS	Median	IV	0.319	0.735	.008	18	view →
ESCA	OS	Median	All	0.617	1.000	.009	15	view →
UCEC	DFS	Tertile	All	0.740	0.633	.012	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

HNF1A-AS1–ACC (OS)

Open the ACC breakdown →