Across TCGA patient cohorts, HMX1 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible HMX1-associated genes across cancer lineages are OR5D2P, MIR4280, and MIR3167. Each is linked with HMX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMX1-to-partner and partner-to-HMX1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMX1→partner) and Y-score (partner→HMX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	OR5D2P →	+0.199	+7.640	<.001	.009	3	1
BLCA	MIR4280 →	+0.938	+7.640	<.001	.009	3	1
BLCA	MIR3167 →	+0.423	+7.640	<.001	.009	3	1
BLCA	MIR6082 →	+0.348	+7.640	<.001	.009	3	1
BLCA	RNU6-832P →	+0.353	+7.640	<.001	.009	3	1
BLCA	RNU6-639P →	+0.588	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

HMX1 survival (RNA) · tumor vs normal (RNA) · all HMX1 data types