HMOX1

Across TCGA patient cohorts, HMOX1 mutation is significantly associated with the RNA expression of many other genes, with 660 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMOX1-associated genes across cancer lineages are TRIM73, CCDC89, and ARID3B. Each is linked with HMOX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMOX1-to-partner and partner-to-HMOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM73 grouped by HMOX1-low versus HMOX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMOX1→partner) and Y-score (partner→HMOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRIM73 →	+0.143	+1.928	<.001	.009	3	1
UCEC	CCDC89 →	-0.822	-3.668	.001	.001	3	1
UCEC	ARID3B →	+0.402	+2.415	.003	.003	3	1
UCEC	DNHD1 →	+0.407	+2.163	<.001	.009	3	1
UCEC	FCER1A →	-0.798	-3.647	.002	.001	3	1
UCEC	RCC1 →	+0.476	+2.163	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 660 associations by consensus.

TRIM73 by HMOX1 expression — UCEC

Explore this box plot interactively →