HMMR

Across TCGA patient cohorts, HMMR RNA expression is significantly associated with the protein abundance of many other proteins, with 21,666 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HMMR-associated proteins across cancer lineages are PTPN2_S304, SMC2, and SMC4. Each is linked with HMMR in more than 9 cancer types. Because this analysis shows association rather than direction, both HMMR-to-partner and partner-to-HMMR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMMR versus PTPN2_S304 in OV, with a Pearson correlation of 0.47.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HMMR→partner) and Y-score (partner→HMMR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PTPN2_S304 →	+0.759	+1.364	<.001	<.001	3	10
GBM	SMC2 →	+0.734	+0.948	<.001	<.001	3	10
GBM	SMC4 →	+0.679	+0.874	<.001	<.001	3	10
OV	POLD1 →	+0.407	+1.035	<.001	<.001	3	10
LUAD	RFC1_T506 →	+1.167	+1.286	<.001	<.001	3	10
BRCA	RIF1 →	+0.438	+0.743	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,666 associations by consensus.

HMMR vs PTPN2_S304 — OV

Explore this scatter interactively →