HMMR-AS1

Across TCGA pan-cancer cohorts, HMMR-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated HMMR-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HMMR-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HMMR-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and READ show a favorable association.

HNSC, ACC, and UCEC are the cancer types where HMMR-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.623	0.293	<.001	100	view →
ACC	OS	Tertile	All	0.723	0.929	.001	81	view →
UCEC	DFS	Quartile	III,IV	0.363	0.636	.012	52	view →
LGG	DFS	Tertile	All	0.596	0.776	<.001	51	view →
DLBC	DFS	Median	All	0.271	0.820	<.001	41	view →
PAAD	DFS	Tertile	All	0.173	0.343	.003	39	view →
CESC	DFS	Median	All	0.777	0.863	.005	38	view →
KIRC	OS	Tertile	All	0.477	0.713	<.001	28	view →
READ	OS	Quartile	II,III,IV	1.000	0.545	.009	28	view →
MESO	DFS	Median	All	0.273	0.416	.008	27	view →
PRAD	OS	Tertile	All	0.958	0.993	.008	24	view →
UVM	OS	Tertile	All	0.293	0.718	.002	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

HMMR-AS1–HNSC (OS)

Open the HNSC breakdown →