HMMR-AS1

Across TCGA pan-cancer cohorts, HMMR-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of HMMR-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where HMMR-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMMR-AS1 is over-expressed in tumor.

BLCA, LUSC, and COAD are the cancer types where HMMR-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMMR-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	+0.089	<.001	10	view →
LUSC	All	All	+0.061	<.001	7	view →
COAD	All	All	+0.077	.003	4	view →
BRCA	All	II,III,IV	+0.063	<.001	4	view →
LUAD	All	All	+0.030	.006	4	view →
READ	All	III,IV	+0.185	<.001	3	view →
STAD	All	All	+0.105	.010	2	view →
HNSC	All	All	+0.021	.013	2	view →
KIRC	All	All	+0.013	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

HMMR-AS1–BLCA

Open the BLCA breakdown →