HMHB1

Across TCGA patient cohorts, HMHB1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMHB1-associated genes across cancer lineages are MIR4499, IGHD5-12, and RN7SKP279. Each is linked with HMHB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMHB1-to-partner and partner-to-HMHB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4499 grouped by HMHB1-low versus HMHB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMHB1→partner) and Y-score (partner→HMHB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4499 →	+0.687	+5.081	<.001	.008	3	1
UCEC	IGHD5-12 →	+1.392	+6.123	<.001	.002	3	1
UCEC	RN7SKP279 →	+0.227	+6.722	<.001	<.001	3	1
UCEC	LINC01706 →	+0.134	+5.621	<.001	.004	3	1
UCEC	RNU6ATAC17P →	+0.682	+5.186	<.001	.007	3	1
UCEC	RNU6-1213P →	+0.914	+6.877	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MIR4499 by HMHB1 expression — UCEC

Explore this box plot interactively →