HMGXB4

Across TCGA patient cohorts, HMGXB4 protein abundance is significantly associated with the RNA expression of many other genes, with 19,794 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HMGXB4-associated genes across cancer lineages are NCAPG, MBTD1, and KIF18A. Each is linked with HMGXB4 in more than 4 cancer types. Because this analysis shows association rather than direction, both HMGXB4-to-partner and partner-to-HMGXB4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMGXB4 versus NCAPG in LSCC, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGXB4→partner) and Y-score (partner→HMGXB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NCAPG →	+1.210	+0.416	<.001	<.001	3	5
LSCC	MBTD1 →	+0.595	+0.273	<.001	<.001	3	5
HNSC	KIF18A →	+0.816	+0.230	<.001	<.001	3	5
LSCC	KHDC4 →	+0.601	+0.280	<.001	<.001	3	5
LSCC	RFC3 →	+0.723	+0.224	<.001	<.001	3	5
LSCC	BRIP1 →	+0.859	+0.256	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,794 associations by consensus.

HMGXB4 vs NCAPG — LSCC

Explore this scatter interactively →