HMGXB4

Across TCGA patient cohorts, HMGXB4 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMGXB4-associated genes across cancer lineages are A-Raf_pS299, FoxM1, and p62 Lck ligand. Each is linked with HMGXB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGXB4-to-partner and partner-to-HMGXB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by HMGXB4-low versus HMGXB4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGXB4→partner) and Y-score (partner→HMGXB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.142	-2.700	.001	.006	3	2
UCEC	FoxM1 →	+0.235	+2.662	.015	<.001	3	2
UCEC	p62 Lck ligand →	+0.359	+2.009	.003	.017	3	2
UCEC	Caspase-8 →	-0.248	-2.673	.008	.005	3	2
UCEC	Cyclin-B1 →	+0.902	+3.321	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.097	-1.973	.010	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

A-Raf_pS299 by HMGXB4 expression — UCEC

Explore this box plot interactively →