HMGXB4

Across TCGA cell cohorts, HMGXB4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,596 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HMGXB4-associated GO terms across cancer lineages are Centriole replication, Negative regulation of chromosome condensation, and U2-type prespliceosome assembly. Each is linked with HMGXB4 in more than 16 cancer types. Because this analysis shows association rather than direction, both HMGXB4-to-partner and partner-to-HMGXB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Centriole replication grouped by HMGXB4-low versus HMGXB4-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGXB4→partner) and Y-score (partner→HMGXB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Centriole replication →	+0.098	+0.682	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome condensation →	+0.185	+0.885	<.001	.003	2	17
BLOOD_Leukemia	U2-type prespliceosome assembly →	+0.081	+0.795	<.001	<.001	3	16
KIDNEY	Microtubule organizing center organization →	+0.083	+1.034	<.001	<.001	3	16
BREAST	Microtubule polymerization or depolymerization →	+0.089	+0.783	<.001	<.001	3	16
SOFT_TISSUE	Heterochromatin formation →	+0.058	+0.481	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,596 associations by consensus.

Centriole replication by HMGXB4 expression — LARGE_INTESTINE

Explore this box plot interactively →