HMGXB4

Across TCGA cell cohorts, HMGXB4 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible HMGXB4-associated genes across cancer lineages are CNPY1, CYP11B1, and OPRPN. Each is linked with HMGXB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGXB4-to-partner and partner-to-HMGXB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNPY1 grouped by HMGXB4-low versus HMGXB4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGXB4→partner) and Y-score (partner→HMGXB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CNPY1 →	+0.307	+3.604	<.001	.004	3	1
LUNG_NSCLC_LUAD	CYP11B1 →	+0.007	+3.362	<.001	.007	3	1
LUNG_NSCLC_LUAD	OPRPN →	+0.034	+3.887	<.001	.002	3	1
LUNG_NSCLC_LUAD	LRRC3B →	+0.125	+3.215	<.001	.007	3	1
LUNG_NSCLC_LUAD	KRTAP19-1 →	+0.358	+3.343	.006	.005	3	1
LUNG_NSCLC_LUAD	KRTAP19-4 →	+0.141	+4.266	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

CNPY1 by HMGXB4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →