HMGXB3

Across TCGA patient cohorts, HMGXB3 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,640 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HMGXB3-associated proteins across cancer lineages are PAIP2B, YTHDC2, and RUFY1. Each is linked with HMGXB3 in more than 4 cancer types. Because this analysis shows association rather than direction, both HMGXB3-to-partner and partner-to-HMGXB3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMGXB3 versus PAIP2B in CCRCC, with a Pearson correlation of -0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGXB3→partner) and Y-score (partner→HMGXB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PAIP2B →	-0.664	-0.346	<.001	<.001	3	4
OV	YTHDC2 →	+0.290	+0.628	.003	.002	2	5
GBM	RUFY1 →	+0.244	+0.341	<.001	<.001	3	4
LSCC	CD38 →	-0.706	-0.343	<.001	<.001	3	4
OV	ERBB3_S686 →	-1.058	-0.477	<.001	.005	3	4
LSCC	HID1 →	-0.522	-0.429	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,640 associations by consensus.

HMGXB3 vs PAIP2B — CCRCC

Explore this scatter interactively →