HMGXB3

Across TCGA patient cohorts, HMGXB3 mutation is significantly associated with the RNA expression of many other genes, with 1,753 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMGXB3-associated genes across cancer lineages are RNA5SP413, MTND5P33, and CCL4. Each is linked with HMGXB3 in more than 2 cancer types. Because this analysis shows association rather than direction, both HMGXB3-to-partner and partner-to-HMGXB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP413 grouped by HMGXB3-low versus HMGXB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGXB3→partner) and Y-score (partner→HMGXB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP413 →	+0.925	+1.862	<.001	<.001	3	3
LIHC	MTND5P33 →	+0.038	+5.758	<.001	.003	3	2
COAD	CCL4 →	+0.978	+3.459	.006	.005	3	2
UCEC	RNA5SP412 →	+0.449	+1.645	<.001	.008	3	2
COAD	SAR1B →	+0.557	+3.459	<.001	.005	3	2
UCEC	DPEP1 →	-1.023	-2.201	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,753 associations by consensus.

RNA5SP413 by HMGXB3 expression — UCEC

Explore this box plot interactively →